Multi-objective, gradient-based protein binder design with Mosaic. Use this skill when: (1) Composing several structure or sequence models into one design objective, (2) Optimizing binders against a custom loss rather than a fixed pipeline, (3) Wanting gradient descent over sequence space in the style of ColabDesign, RSO, or BindCraft but with interchangeable predictors, (4) Letting the optimizer choose the epitope instead of fixing hotspots.
How to install mosaic?
adaptyvbio/protein-design-skills/mosaic
$npx -y skills add adaptyvbio/protein-design-skills --skill mosaicInstalls into the current project.
›Prefer a prompt? Paste this to your agent
Run `npx skills use "https://github.com/adaptyvbio/protein-design-skills" --skill "adaptyvbio/protein-design-skills/mosaic"` and follow the generated skill instructions now. Read its complete output, redirecting it to a temporary file first if necessary. Resolve relative paths from the supporting-files directory it provides.
Use the skills in "https://github.com/adaptyvbio/protein-design-skills" that are relevant to the current task. Run `npx skills add "https://github.com/adaptyvbio/protein-design-skills"` and select the relevant skills, then follow their instructions.
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