$npx -y skills add anthropics/knowledge-work-plugins --skill startSet up your bio-research environment and explore available tools. Use when first getting oriented with the plugin, checking which literature, drug-discovery, or visualization MCP servers are connected, or surveying available analysis skills before starting a new project.
| 1 | # Bio-Research Start |
| 2 | |
| 3 | > If you see unfamiliar placeholders or need to check which tools are connected, see [CONNECTORS.md](../../CONNECTORS.md). |
| 4 | |
| 5 | You are helping a biological researcher get oriented with the bio-research plugin. Walk through the following steps in order. |
| 6 | |
| 7 | ## Step 1: Welcome |
| 8 | |
| 9 | Display this welcome message: |
| 10 | |
| 11 | ``` |
| 12 | Bio-Research Plugin |
| 13 | |
| 14 | Your AI-powered research assistant for the life sciences. This plugin brings |
| 15 | together literature search, data analysis pipelines, |
| 16 | and scientific strategy — all in one place. |
| 17 | ``` |
| 18 | |
| 19 | ## Step 2: Check Available MCP Servers |
| 20 | |
| 21 | Test which MCP servers are connected by listing available tools. Group the results: |
| 22 | |
| 23 | **Literature & Data Sources:** |
| 24 | - ~~literature database — biomedical literature search |
| 25 | - ~~literature database — preprint access (biology and medicine) |
| 26 | - ~~journal access — academic publications |
| 27 | - ~~data repository — collaborative research data (Sage Bionetworks) |
| 28 | |
| 29 | **Drug Discovery & Clinical:** |
| 30 | - ~~chemical database — bioactive compound database |
| 31 | - ~~drug target database — drug target discovery platform |
| 32 | - ClinicalTrials.gov — clinical trial registry |
| 33 | - ~~clinical data platform — clinical trial site ranking and platform help |
| 34 | |
| 35 | **Visualization & AI:** |
| 36 | - ~~scientific illustration — create scientific figures and diagrams |
| 37 | - ~~AI research platform — AI for biology (histopathology, drug discovery) |
| 38 | |
| 39 | Report which servers are connected and which are not yet set up. |
| 40 | |
| 41 | ## Step 3: Survey Available Skills |
| 42 | |
| 43 | List the analysis skills available in this plugin: |
| 44 | |
| 45 | | Skill | What It Does | |
| 46 | |-------|-------------| |
| 47 | | **Single-Cell RNA QC** | Quality control for scRNA-seq data with MAD-based filtering | |
| 48 | | **scvi-tools** | Deep learning for single-cell omics (scVI, scANVI, totalVI, PeakVI, etc.) | |
| 49 | | **Nextflow Pipelines** | Run nf-core pipelines (RNA-seq, WGS/WES, ATAC-seq) | |
| 50 | | **Instrument Data Converter** | Convert lab instrument output to Allotrope ASM format | |
| 51 | | **Scientific Problem Selection** | Systematic framework for choosing research problems | |
| 52 | |
| 53 | ## Step 4: Optional Setup — Binary MCP Servers |
| 54 | |
| 55 | Mention that two additional MCP servers are available as separate installations: |
| 56 | |
| 57 | - **~~genomics platform** — Access cloud analysis data and workflows |
| 58 | Install: Download `txg-node.mcpb` from https://github.com/10XGenomics/txg-mcp/releases |
| 59 | - **~~tool database** (Harvard MIMS) — AI tools for scientific discovery |
| 60 | Install: Download `tooluniverse.mcpb` from https://github.com/mims-harvard/ToolUniverse/releases |
| 61 | |
| 62 | These require downloading binary files and are optional. |
| 63 | |
| 64 | ## Step 5: Ask How to Help |
| 65 | |
| 66 | Ask the researcher what they're working on today. Suggest starting points based on common workflows: |
| 67 | |
| 68 | 1. **Literature review** — "Search ~~literature database for recent papers on [topic]" |
| 69 | 2. **Analyze sequencing data** — "Run QC on my single-cell data" or "Set up an RNA-seq pipeline" |
| 70 | 3. **Drug discovery** — "Search ~~chemical database for compounds targeting [protein]" or "Find drug targets for [disease]" |
| 71 | 4. **Data standardization** — "Convert my instrument data to Allotrope format" |
| 72 | 5. **Research strategy** — "Help me evaluate a new project idea" |
| 73 | |
| 74 | Wait for the user's response and guide them to the appropriate tools and skills. |