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…/bioskills/heritability-partitioning
home/skills/gptomics/bioskills/heritability-partitioning
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heritability-partitioning

bygptomics· 59 skills

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1.1k

Forks

187

Category

Data Science & Analytics

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TL;DR

Estimates SNP heritability and partitions it across functional annotations, cell types, and loci from GWAS summary statistics or individual-level genotypes. Implements LDSC, stratified LDSC with the baseline-LD model, Finucane 2018 cell-type prioritization, LDAK SumHer, HDL, HESS local heritability, BOLT-REML, GCTA-GREML, graphREML, and Popcorn cross-population genetic correlation. Use when computing total h2_SNP from summary stats, partitioning heritability across functional categories, prioritizing trait-relevant tissues or cell types from ENCODE/Roadmap chromatin marks, reconciling LDSC vs LDAK enrichment estimates, computing local heritability with HESS, estimating genetic correlation between traits, or producing publication-grade enrichment with calibrated sensitivity to model assumptions.

How to install heritability-partitioning?

gptomics/bioskills/heritability-partitioning
$npx -y skills add gptomics/bioskills --skill heritability-partitioning

Installs into the current project.

›Prefer a prompt? Paste this to your agent

Use this skill

Run `npx skills use "https://github.com/gptomics/bioskills" --skill "gptomics/bioskills/heritability-partitioning"` and follow the generated skill instructions now. Read its complete output, redirecting it to a temporary file first if necessary. Resolve relative paths from the supporting-files directory it provides.

Use the whole pack

Use the skills in "https://github.com/gptomics/bioskills" that are relevant to the current task. Run `npx skills add "https://github.com/gptomics/bioskills"` and select the relevant skills, then follow their instructions.

Preview

gptomics/bioskillsgptomics/bioskills

$ npx -y skills add gptomics/bioskills --skill heritability-partitioning

▸ installing to .claude/skills…

✓ heritability-partitioning ready

Repogptomics/bioskills
TypeSkills
CategoryData Science & Analytics
ForResearcherAnalyst
UpdatedJul 2026
License—
First seenJul 27, 2026

Tags

Skill

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