Use when computing free energy differences for drug discovery. Covers FEP/TI/BAR/MBAR theory, alchemical transformations with OpenMMTools, relative binding free energy (RBFE) protocols, absolute binding free energy (ABFE), pymbar analysis, convergence diagnostics, and standard state corrections.
How to install free-energy?
kdevos12/alkyl/free-energy
$npx -y skills add kdevos12/alkyl --skill free-energyInstalls into the current project.
›Prefer a prompt? Paste this to your agent
Run `npx skills use "https://github.com/kdevos12/alkyl" --skill "kdevos12/alkyl/free-energy"` and follow the generated skill instructions now. Read its complete output, redirecting it to a temporary file first if necessary. Resolve relative paths from the supporting-files directory it provides.
Use the skills in "https://github.com/kdevos12/alkyl" that are relevant to the current task. Run `npx skills add "https://github.com/kdevos12/alkyl"` and select the relevant skills, then follow their instructions.
Related
6 picksType
- azure-aiUse for Azure AI: Search, Speech, OpenAI, Document Intelligence. Helps with search, vector/hybrid search, speech-to-text, text-to-speech, transcription, OCR.Jul 2026
- ai-research-exploreRigor Explore compatible skill slug for meaningful and potentially novel deep learning research candidates.Jul 2026
- ai-research-reproductionRigor Reproduce compatible skill slug for README-first deep learning repository reproduction.Jul 2026
- explore-codeRigor Improve implementation leaf skill for auditable candidate implementation in deep learning research repositories.Jul 2026
- run-trainRigor Train skill for deep learning research repositories. Use when a documented or selected training command should be run conservatively for startup…Jul 2026
- explore-runRigor Improve / Rigor Explore run leaf skill for bounded exploratory evidence in deep learning research repositories.Jul 2026
