drugcomb

Name: drugcomb
Author: QSong-github

132stars4forks

How to install drugcomb?

qsong-github/drugclaw/drugcomb

$npx -y skills add QSong-github/DrugClaw --skill drugcomb

Installs into the current project.

Summary

Query the DrugComb drug combination database for cancer cell-line synergy and sensitivity data. Use whenever the user asks about drug combinations, synergy scores (ZIP/Bliss/Loewe/HSA), combination sensitivity (CSS), or wants to look up how two drugs interact in a specific cancer

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SKILL.md

1	# DrugComb Query Skill
2
3	Search DrugComb summary records by any entity. Auto-detects type by pattern:
4
5	\| Input Pattern \| Detected As \| Match Logic \|
6	\|---\|---\|---\|
7	\| `5-FU` / `imatinib` \| drug name \| case-insensitive substring on `drug_row` OR `drug_col` \|
8	\| `A549` / `MCF-7` \| cell line \| case-insensitive substring on `cell_line_name` \|
9	\| `12345` (pure digits) \| block_id \| exact on `block_id` \|
10	\| `CID:2244` \| PubChem CID \| exact on `drug_row_cid` OR `drug_col_cid` \|
11
12	## API
13
14	\| Function \| Input \| Returns \|
15	\|---\|---\|---\|
16	\| `load_drugcomb(path)` \| CSV path \| `list[dict]` \|
17	\| `columns(data)` \| loaded data \| column name list \|
18	\| `search(data, entity)` \| single entity string \| `list[dict]` \|
19	\| `search_batch(data, entities)` \| list of entity strings \| `dict[str, list[dict]]` \|
20	\| `summarize(hits, entity)` \| hit list + label \| compact LLM-readable text \|
21	\| `to_json(hits)` \| hit list \| `list[dict]` \|
22
23	## Usage
24
25	See `if __name__ == "__main__"` block in `example.py` for runnable examples covering: drug name search, cell-line search, batch search, and JSON output.
26
27	## Data
28
29	- Source: DrugComb normalized full-package output
30	- Key columns: `drug_row`, `drug_col`, `cell_line_name`, `synergy_zip`, `synergy_bliss`
31	- Path: `resources_metadata/drug_combination/DrugComb/drugcomb.csv`
32
33	## Citation
34
35	Zagidullin B, Aldahdooh J, Zheng S, et al. DrugComb: an integrative cancer drug combination data portal. Nucleic Acids Res. 2019;47(W1):W43–W51. doi:10.1093/nar/gkz337

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drugcomb

132stars4forks

View on GitHub

How to install drugcomb?

qsong-github/drugclaw/drugcomb

$npx -y skills add QSong-github/DrugClaw --skill drugcomb

Installs into the current project.

Summary

Files · 1

View on GitHub

SKILL.md

1	# DrugComb Query Skill
2
3	Search DrugComb summary records by any entity. Auto-detects type by pattern:
4
5	\| Input Pattern \| Detected As \| Match Logic \|
6	\|---\|---\|---\|
7	\| `5-FU` / `imatinib` \| drug name \| case-insensitive substring on `drug_row` OR `drug_col` \|
8	\| `A549` / `MCF-7` \| cell line \| case-insensitive substring on `cell_line_name` \|
9	\| `12345` (pure digits) \| block_id \| exact on `block_id` \|
10	\| `CID:2244` \| PubChem CID \| exact on `drug_row_cid` OR `drug_col_cid` \|
11
12	## API
13
14	\| Function \| Input \| Returns \|
15	\|---\|---\|---\|
16	\| `load_drugcomb(path)` \| CSV path \| `list[dict]` \|
17	\| `columns(data)` \| loaded data \| column name list \|
18	\| `search(data, entity)` \| single entity string \| `list[dict]` \|
19	\| `search_batch(data, entities)` \| list of entity strings \| `dict[str, list[dict]]` \|
20	\| `summarize(hits, entity)` \| hit list + label \| compact LLM-readable text \|
21	\| `to_json(hits)` \| hit list \| `list[dict]` \|
22
23	## Usage
24
25	See `if __name__ == "__main__"` block in `example.py` for runnable examples covering: drug name search, cell-line search, batch search, and JSON output.
26
27	## Data
28
29	- Source: DrugComb normalized full-package output
30	- Key columns: `drug_row`, `drug_col`, `cell_line_name`, `synergy_zip`, `synergy_bliss`
31	- Path: `resources_metadata/drug_combination/DrugComb/drugcomb.csv`
32
33	## Citation
34
35	Zagidullin B, Aldahdooh J, Zheng S, et al. DrugComb: an integrative cancer drug combination data portal. Nucleic Acids Res. 2019;47(W1):W43–W51. doi:10.1093/nar/gkz337

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6 picks

Type