Design group sequential clinical trials for survival endpoints (OS, PFS, DFS) with interim analyses, spending functions, boundaries, multiplicity, and event/enrollment prediction. Triggers on: Phase 3 trial design, sample size/events for survival endpoints, alpha spending, group sequential design, interim analysis planning, or enrollment/event timeline prediction for clinical trials.
$npx -y skills add rconsortium/pharma-skills --skill group-sequential-designInstalls into the current project.
Run `npx skills use "https://github.com/rconsortium/pharma-skills" --skill "rconsortium/pharma-skills/group-sequential-design"` and follow the generated skill instructions now. Read its complete output, redirecting it to a temporary file first if necessary. Resolve relative paths from the supporting-files directory it provides.
Use the skills in "https://github.com/rconsortium/pharma-skills" that are relevant to the current task. Run `npx skills add "https://github.com/rconsortium/pharma-skills"` and select the relevant skills, then follow their instructions.