Inverse-fold a backbone with SolubleMPNN — ProteinMPNN retrained on a soluble-PDB subset (Dauparas et al. 2022) — for sequences biased toward cytosolic expression and reduced aggregation. Reach for this skill when designs from vanilla ProteinMPNN are aggregating or going to inclusion bodies, when redesigning a membrane-adjacent fold for soluble expression, or when an E. coli expression screen is the next step.
How to install solublempnn?
xuzhougeng/wisp-science/solublempnn
$npx -y skills add xuzhougeng/wisp-science --skill solublempnnInstalls into the current project.
›Prefer a prompt? Paste this to your agent
Run `npx skills use "https://github.com/xuzhougeng/wisp-science" --skill "xuzhougeng/wisp-science/solublempnn"` and follow the generated skill instructions now. Read its complete output, redirecting it to a temporary file first if necessary. Resolve relative paths from the supporting-files directory it provides.
Use the skills in "https://github.com/xuzhougeng/wisp-science" that are relevant to the current task. Run `npx skills add "https://github.com/xuzhougeng/wisp-science"` and select the relevant skills, then follow their instructions.
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